基本信息

彭韵桦课题组围绕蛋白质翻译后修饰，包括泛素化和去泛素化及其相关靶向蛋白质降解技术，在肿瘤微环境、代谢性疾病等领域开展学术研究。

主持的项目包括：国家自然科学基金面上项目、国家自然科学基金青年项目、陕西省自然科学基础研究计划、中国博士后基金一等资助、西安市科协青年人才托举计划、西安交通大学青年骨干培植项目等。

参与的项目包括：国家重点研发计划、国家自然科学基金、陕西省重点项目等。

在Cell Research、Trends in Cell Biology、Nature Communications、Seminars in Cancer Biology、Cell Death and Differentiation、 Pharmacological Research 等期刊发表学术论文40余篇，他引1200余次，1篇论文入选ESI全球Top1%高被引论文。参编图书教材2部。获专利3项。

获得中国生物物理学会优秀青年学者、西安市科协青年托举人才、陕西省研究生创新成果展一等奖（第1完成人）、Oxygen Club of California青年研究者奖。

指导学生获批国家大学生创新创业项目、陕西省大学生创新创业项目。指导学生获得腾飞杯竞赛、陕西省研究生创新成果展等奖项。

 

办公地点：创新港18号巨构（泓生楼）

邮箱: y.peng@mail.xjtu.edu.cn

通讯方式：陕西省西安市咸宁西路28号 西安交通大学 710049

研究简介

研究领域：

  • 肿瘤微环境：蛋白质翻译后修饰 + 靶向蛋白质降解药物开发

  • 代谢性疾病：能量代谢重编程 + 靶向能量代谢营养素筛选

 

Publications：

*: These authors contribute equally to this work, #: co-correspondence

  1. Y. Peng*, D. Liu*, D. Huang, H. Inuzuka#, J. Liu#. PROTAC as a novel anti-cancer strategy by targeting aging-related signaling. Seminars in Cancer Biology 106-107 (2024) 143-155. 
  2. J. Ma*, L. Li*, B.Ma*, T. Liu, Z. Wang, Q. Ye, Y. Peng, B. Wang, Y. Chen, S. Xu, K. Wang, F. Dang, X. Wang, Z. Zeng, Y. Jian, Z. Ren, Y. Fan, X. Li, J. Liu, Y. Gao, W. Wei, L. Li#, MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation. Nature Communications 15(1) (2024) 1871. 
  3. Y. Hu, Y. Wang, Y. Wang, Y. Zhang, Z. Wang, X. Xu, T. Zhang, T. Zhang, S. Zhang, R. Hu, L. Shi, X. Wang, J. Li, H. Shen, J. Liu, M. Noda, Y. Peng#, J. Long#. Sleep Deprivation Triggers Mitochondrial DNA Release in Microglia to Induce Neural Inflammation: Preventative Effect of Hydroxytyrosol Butyrate. Antioxidants (Basel, Switzerland) 13(7) (2024) 833. 
  4. T. Han, Y. Peng, Y. Du, Y. Li, Y. Wang, W. Sun, L. Cui, Q. Peng#. Mining Alzheimer's disease clinical data: reducing effects of natural aging for predicting progression and identifying subtypes. Frontiers in Neuroscience 18 (2024) 1388391. 
  5. 王颖, 王一方, 罗朝桂, 刘健康, 龙建纲, 彭韵桦#. 脂肪肝中的线粒体氧化应激分子机制及营养素干预策略. 中国科学:生命科学(2024).
  6. Y. Peng*, J. Liu*, H. Inuzuka, W. Wei#, Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy, Journal of Biological Chemistry 299(4) (2023) 104572. 
  7. X. Guo*, Y. Peng*, Q. Song*, J.Wei, X. Wang, Y. Ru, S. Xu, X Cheng, X. Li, D.Wu, L. Chen, B. Wei#, X. Lv#, Ji, G#, A liquid biopsy signature for the early-detection of patients with gastric cancer, Gastroenterology (2023) S0016-5085(23)00236-6.
  8. 彭韵桦, 刘莎, 崔莉, 刘健康, 龙建纲#, 靶向蛋白质泛素修饰及降解在前列腺癌治疗中的机遇与挑战.生物化学与生物物理进展 50(4) (2023) 782-794.
  9. Y. Peng*, J. Liu*, Z. Wang*, C. Cui*, T. Zhang, S. Zhang, P. Gao, Z. Hou, H. Liu, J. Guo, J. Zhang, Y. Wen, W. Wei, L. Zhang#, J. Liu#, J. Long#, Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc, Cell Death and Differentiation 29(9) (2022) 1730-1743.
  10. J. Liu*, Y. Peng*, H. Inuzuka, W. Wei#, Targeting micro-environmental pathways by PROTACs as a therapeutic strategy, Seminars in Cancer Biology 86(Pt 2) (2022) 269-279.
  11. P. Gao*, Z. Wang*, M. Lei, J. Che, S. Zhang, T. Zhang, Y. Hu, L. Shi, L. Cui, J. Liu, M. Noda, Y. Peng#, J. Long#, Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease, Pharmacological Research 180 (2022) 106227.
  12. Y. Peng, H. Liu#, J. Liu, J. Long#, Post-translational modifications on mitochondrial metabolic enzymes in cancer, Free Radical Biology & Medicine 179 (2022) 11-23.
  13. J. Liu*, Y. Peng*, W. Wei#, Cell cycle on the crossroad of tumorigenesis and cancer therapy, Trends in Cell Biology 32(1) (2022) 30-44.[ESI高被引论文]
  14. T. Zhang*, S. Zhang*, Y. Peng#, Y. Wang, P. Gao, Y. Hu, Z. Wang, M. Noda, M. Hiramatsu, J. Liu, J. Long#, Safflower leaf ameliorates cognitive impairment through moderating excessive astrocyte activation in APP/PS1 mice, Food & Function 12(22) (2021) 11704-11716.
  15. J. Liu*, Y. Peng*, W. Wei#, Light-controllable PROTACs for temporospatial control of protein degradation, Frontiers in Cell and Developmental Biology 9 (2021) 678077.
  16. J. Liu*, Y. Peng*, L. Shi*, L. Wan, H. Inuzuka, J. Long, J. Guo, J. Zhang, M. Yuan, S. Zhang, X. Wang, J. Gao, X. Dai, S. Furumoto, L. Jia, P.P. Pandolfi, J.M. Asara, W.G. Kaelin, Jr., J. Liu#, W. Wei#, Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle, Cell Research 31(1) (2021) 80-93.
  17. C. Qin, S. Hu, S. Zhang, D. Zhao, Y. Wang, H. Li, Y. Peng, L. Shi, X. Xu, C. Wang, J. Liu, Y. Cheng#, J. Long#, Hydroxytyrosol acetate improves the cognitive function of APP/PS1 transgenic mice in ERβ-dependent manner, Molecular Nutrition & Food Research 65(3) (2021) e2000797.
  18. Y. Peng, P. Gao, L. Shi, L. Chen, J. Liu#, J. Long#, Central and peripheral metabolic defects contribute to the pathogenesis of Alzheimer's disease: targeting mitochondria for diagnosis and prevention, Antioxidants & Redox Signaling 32(16) (2020) 1188-1236.
  19. L. Shi, D. Du, Y. Peng, J. Liu, J#. Long#, The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer, Oncogenesis 9(10) (2020) 98.
  20. L. Shi, J. Liu, Y. Peng, J. Zhang, X. Dai, S. Zhang, Y. Wang, J. Liu, J#. Long#, Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission, Molecular Oncology 14(12) (2020) 3169-3183.
  21. J. Liu, Y. Peng, J. Zhang, J. Long, J. Liu#, W. Wei#, Targeting SCF E3 ligases for cancer therapies, Advances in Experimental Medicine and Biology 1217 (2020) 123-146.
  22. D. Du, Y. Peng, J. Liu, J. Long. Progress in the use of molecular hydrogen for cancer treatment, Journal of Nutritional Oncology 4(3) (2019) 103-108.
  23. Z. Wang, P. Gao, Y. Peng, J. Liu, J. Long, Gender difference in the pathogenesis of Alzheimer's disease, Progress in Biochemistry and Biophysics 46(5) (2019) 449-455.
  24. C. Hou*, Y. Peng*, C. Qin, F. Fan, J. Liu#, J. Long#, Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance, Free Radical Research 52(11-12) (2018) 1311-1322.
  25. L. Shi, D. Zhao, C. Hou, Y. Peng, J. Liu, S. Zhang, J. Liu#, J. Long#, Early interleukin-6 enhances hepatic ketogenesis in APP(SWE)/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65, Neurobiology of Aging 56 (2017) 115-126.
  26. Z. Lu, H. Li, C. Hou, Y. Peng, J. Long#, J. Liu#, Endogenously generated amyloid-β increases stiffness in human neuroblastoma cells, European Biophysics Journal 46(5) (2017) 415-424.
  27. Y. Peng*, C. Hou*, Z. Yang, C. Li, L. Jia, J. Liu, Y. Tang, L. Shi, Y. Li, J. Long#, J. Liu#, Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice, Molecular Nutrition & Food Research 60(11) (2016) 2331-2342.
  28. Y. Peng, J. Liu, L. Shi, Y. Tang, D. Gao, J. Long#, J. Liu#, Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons, Journal of Neurochemistry 137(5) (2016) 701-13.
  29. J. Liu*, Y. Peng*, X. Wang, Y. Fan, C. Qin, L. Shi, Y. Tang, K. Cao, H. Li, J. Long#, J. Liu#, Mitochondrial dysfunction launches dexamethasone-induced skeletal muscle atrophy via AMPK/FOXO3 signaling, Molecular Pharmaceutics 13(1) (2016) 73-84.
  30. Y. Tang, Y. Peng, J. Liu, L. Shi, Y. Wang, J. Long#, J. Liu#, Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APP(SWE) /PSEN1dE9 mouse model of Alzheimer's disease, Journal of Neurochemistry 136(4) (2016) 791-803.
  31. A. Zheng, H. Li, J. Xu, K. Cao, H. Li, W. Pu, Z. Yang, Y. Peng, J. Long, J. Liu#, Z. Feng#, Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation, British Journal of Nutrition 113(11) (2015) 1667-76.
  32. Y. Peng, J. Liu, Y. Tang, J. Liu, T. Han, S. Han, H. Li, C. Hou, J. Liu#, J. Long#, High-fat-diet-induced weight gain ameliorates bone loss without exacerbating AβPP processing and cognition in female APP/PS1 mice, Frontiers in Cellular Neuroscience 8 (2014) 225.
  33. K. Cao, A. Zheng, J. Xu, H. Li, J. Liu, Y. Peng, J. Long, X. Zou, Y. Li, C. Chen, J. Liu#, Z. Feng#, AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress, Free Radical Biology & Medicine 75 (2014) 156-66.
  34. J. Liu, Y. Peng, Z. Feng, W. Shi, L. Qu, Y. Li, J. Liu#, J. Long#, Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients, Free Radical Biology & Medicine 69 (2014) 116-28.
  35. J. Liu, Y. Peng, Z. Cui, Z. Wu, A. Qian, P. Shang, L. Qu, Y. Li, J. Liu#, J. Long#, Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4-week hindlimb unloading, IUBMB Life 64(11) (2012) 901-10.
  36. J. Liu, Y. Peng, J. Long#, The role of brain mitochondrial estrogen receptor β in the pathogenesis of female Alzheimer's disease, Progress in Biochemistry and Biophysics 39(8) (2012) 785-790.

 

教育和工作经历

2021~至今，副教授，西安交通大学，生命学院

2018~2020，助理教授，西安交通大学，前沿科学技术研究院

2015~2017，联合培养博士，哈佛医学院，BIDMC

2011~2017，博士，西安交通大学，前沿科学技术研究院

2007~2011，学士，西安交通大学，生物工程

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