研究领域：

• 蛋白质翻译后修饰
• 能量代谢重编程
• 肿瘤微环境
• 靶向蛋白质降解药物开发
• 靶向能量代谢营养素筛选

Publications：

*: These authors contribute equally to this work, #: co-correspondence

1. J. Ma*, L. Li*, B.Ma*, T. Liu, Z. Wang, Q.Ye, Y. Peng, B.Wang, Y. Chen, S. Xu, K. Wang, F. Dang, X. Wang, Z. Zeng, Y. Jian, Z. Ren, Y. Fan, X. Li, J. Liu, Y. Gao, W. Wei, L. Li#, MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation. Nature Communications 15(1) (2024) 1871. 
2. Y. Peng*, J. Liu*, H. Inuzuka, W. Wei#, Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy, Journal of Biological Chemistry 299(4) (2023) 104572. 
3. X. Guo*, Y. Peng*, Q. Song*, J.Wei, X. Wang, Y. Ru, S. Xu, X Cheng, X. Li, D.Wu, L. Chen, B. Wei#, X. Lv#, Ji, G#, A liquid biopsy signature for the early-detection of patients with gastric cancer, Gastroenterology (2023) S0016-5085(23)00236-6.
4. 彭韵桦, 刘莎, 崔莉, 刘健康, 龙建纲#, 靶向蛋白质泛素修饰及降解在前列腺癌治疗中的机遇与挑战.生物化学与生物物理进展 50(4) (2023) 782-794.
5. Y. Peng*, J. Liu*, Z. Wang*, C. Cui*, T. Zhang, S. Zhang, P. Gao, Z. Hou, H. Liu, J. Guo, J. Zhang, Y. Wen, W. Wei, L. Zhang#, J. Liu#, J. Long#, Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc, Cell Death and Differentiation 29(9) (2022) 1730-1743.
6. J. Liu*, Y. Peng*, H. Inuzuka, W. Wei#, Targeting micro-environmental pathways by PROTACs as a therapeutic strategy, Seminars in Cancer Biology 86(Pt 2) (2022) 269-279.
7. P. Gao*, Z. Wang*, M. Lei, J. Che, S. Zhang, T. Zhang, Y. Hu, L. Shi, L. Cui, J. Liu, M. Noda, Y. Peng#, J. Long#, Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease, Pharmacological Research 180 (2022) 106227.
8. Y. Peng, H. Liu#, J. Liu, J. Long#, Post-translational modifications on mitochondrial metabolic enzymes in cancer, Free Radical Biology & Medicine 179 (2022) 11-23.
9. J. Liu*, Y. Peng*, W. Wei#, Cell cycle on the crossroad of tumorigenesis and cancer therapy, Trends in Cell Biology 32(1) (2022) 30-44.
10. T. Zhang*, S. Zhang*, Y. Peng#, Y. Wang, P. Gao, Y. Hu, Z. Wang, M. Noda, M. Hiramatsu, J. Liu, J. Long#, Safflower leaf ameliorates cognitive impairment through moderating excessive astrocyte activation in APP/PS1 mice, Food & Function 12(22) (2021) 11704-11716.
11. J. Liu*, Y. Peng*, W. Wei#, Light-controllable PROTACs for temporospatial control of protein degradation, Frontiers in Cell and Developmental Biology 9 (2021) 678077.
12. J. Liu*, Y. Peng*, L. Shi*, L. Wan, H. Inuzuka, J. Long, J. Guo, J. Zhang, M. Yuan, S. Zhang, X. Wang, J. Gao, X. Dai, S. Furumoto, L. Jia, P.P. Pandolfi, J.M. Asara, W.G. Kaelin, Jr., J. Liu#, W. Wei#, Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle, Cell Research 31(1) (2021) 80-93.
13. C. Qin, S. Hu, S. Zhang, D. Zhao, Y. Wang, H. Li, Y. Peng, L. Shi, X. Xu, C. Wang, J. Liu, Y. Cheng#, J. Long#, Hydroxytyrosol acetate improves the cognitive function of APP/PS1 transgenic mice in ERβ-dependent manner, Molecular Nutrition & Food Research 65(3) (2021) e2000797.
14. Y. Peng, P. Gao, L. Shi, L. Chen, J. Liu#, J. Long#, Central and peripheral metabolic defects contribute to the pathogenesis of Alzheimer's disease: targeting mitochondria for diagnosis and prevention, Antioxidants & Redox Signaling 32(16) (2020) 1188-1236.
15. L. Shi, D. Du, Y. Peng, J. Liu, J#. Long#, The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer, Oncogenesis 9(10) (2020) 98.
16. L. Shi, J. Liu, Y. Peng, J. Zhang, X. Dai, S. Zhang, Y. Wang, J. Liu, J#. Long#, Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission, Molecular Oncology 14(12) (2020) 3169-3183.
17. J. Liu, Y. Peng, J. Zhang, J. Long, J. Liu#, W. Wei#, Targeting SCF E3 ligases for cancer therapies, Advances in Experimental Medicine and Biology 1217 (2020) 123-146.
18. D. Du, Y. Peng, J. Liu, J. Long. Progress in the use of molecular hydrogen for cancer treatment, Journal of Nutritional Oncology 4(3) (2019) 103-108.
19. Z. Wang, P. Gao, Y. Peng, J. Liu, J. Long, Gender difference in the pathogenesis of Alzheimer's disease, Progress in Biochemistry and Biophysics 46(5) (2019) 449-455.
20. C. Hou*, Y. Peng*, C. Qin, F. Fan, J. Liu#, J. Long#, Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance, Free Radical Research 52(11-12) (2018) 1311-1322.
21. L. Shi, D. Zhao, C. Hou, Y. Peng, J. Liu, S. Zhang, J. Liu#, J. Long#, Early interleukin-6 enhances hepatic ketogenesis in APP(SWE)/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65, Neurobiology of Aging 56 (2017) 115-126.
22. Z. Lu, H. Li, C. Hou, Y. Peng, J. Long#, J. Liu#, Endogenously generated amyloid-β increases stiffness in human neuroblastoma cells, European Biophysics Journal 46(5) (2017) 415-424.
23. Y. Peng*, C. Hou*, Z. Yang, C. Li, L. Jia, J. Liu, Y. Tang, L. Shi, Y. Li, J. Long#, J. Liu#, Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice, Molecular Nutrition & Food Research 60(11) (2016) 2331-2342.
24. Y. Peng, J. Liu, L. Shi, Y. Tang, D. Gao, J. Long#, J. Liu#, Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons, Journal of Neurochemistry 137(5) (2016) 701-13.
25. J. Liu*, Y. Peng*, X. Wang, Y. Fan, C. Qin, L. Shi, Y. Tang, K. Cao, H. Li, J. Long#, J. Liu#, Mitochondrial dysfunction launches dexamethasone-induced skeletal muscle atrophy via AMPK/FOXO3 signaling, Molecular Pharmaceutics 13(1) (2016) 73-84.
26. Y. Tang, Y. Peng, J. Liu, L. Shi, Y. Wang, J. Long#, J. Liu#, Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APP(SWE) /PSEN1dE9 mouse model of Alzheimer's disease, Journal of Neurochemistry 136(4) (2016) 791-803.
27. A. Zheng, H. Li, J. Xu, K. Cao, H. Li, W. Pu, Z. Yang, Y. Peng, J. Long, J. Liu#, Z. Feng#, Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation, British Journal of Nutrition 113(11) (2015) 1667-76.
28. Y. Peng, J. Liu, Y. Tang, J. Liu, T. Han, S. Han, H. Li, C. Hou, J. Liu#, J. Long#, High-fat-diet-induced weight gain ameliorates bone loss without exacerbating AβPP processing and cognition in female APP/PS1 mice, Frontiers in Cellular Neuroscience 8 (2014) 225.
29. K. Cao, A. Zheng, J. Xu, H. Li, J. Liu, Y. Peng, J. Long, X. Zou, Y. Li, C. Chen, J. Liu#, Z. Feng#, AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress, Free Radical Biology & Medicine 75 (2014) 156-66.
30. J. Liu, Y. Peng, Z. Feng, W. Shi, L. Qu, Y. Li, J. Liu#, J. Long#, Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients, Free Radical Biology & Medicine 69 (2014) 116-28.
31. J. Liu, Y. Peng, Z. Cui, Z. Wu, A. Qian, P. Shang, L. Qu, Y. Li, J. Liu#, J. Long#, Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4-week hindlimb unloading, IUBMB Life 64(11) (2012) 901-10.
32. J. Liu, Y. Peng, J. Long#, The role of brain mitochondrial estrogen receptor β in the pathogenesis of female Alzheimer's disease, Progress in Biochemistry and Biophysics 39(8) (2012) 785-790.