Handling a small volume of liquids at high precision and throughput is fundamental to large-scale biochemistry screening experiments. Our lab is skilled in micropump design & integration for POC, micro-droplet manipulation either passively by structure or actively by electrical force, handling of various syringe pumps, thermal control for PCR, blood separation & micro-magnetic particle-based immunoassay and cell culture through microfluidic devices.

We initiated and developed the workflow and new analysis method for single-cell metabolites study employing droplet printing and MALDI-MS imaging to solve directed evolution issues in synthetic biology and multimodal omics study at the single-cell level.

Continuing our interest in mass spectrometry and droplet microfluidics, we further developed my method for brain tissues at spatial and multimodal omics level to study how the plaque caused by Alzheimer’s disease interfere with neighboring cells.