Juan Yang, Ph.D, Prof. Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center.

Address: Health Science Center, Xi'an Jiaotong University, 76 West Yanta Road, Xi 'an Shaanxi, 710061, P.R. China

E-mail: yangjuan0112@xjtu.edu.cn

WeChat:

2019.01- Present:  Professor, School of Basic Medical Sciences, Xi’an Jiaotong University, China.

2018.06- Present: Doctoral Supervisor, School of Basic Medical Sciences, Xi’an Jiaotong University, China.

2017.09-2018.09: Visiting Scholar, School of Biomedical Informatics, Health Science Center at Houston, The University of Texas, USA.

2013.06- Present: Master's Supervisor, School of Basic Medical Sciences, Xi’an Jiaotong University, China.

2013.01-2018.12: Associate Professor, School of Basic Medical Sciences, Xi’an Jiaotong University, China.

2008.07-2012.12:  Lecturer, School of Basic Medical Sciences, Xi’an Jiaotong University, China.

Biomarkers:

My research focuses on the identification and validation of biomarkers for early diagnosis and treatment of Cancers or other diseases based on proteomic and genomic analyses. Also investigated the candidate molecules function by cell biology and early diagnosis and treatment of Cancers or other diseases based on proteomic and molecular biology techniques.

Psychological Stress & disease:

My research also focuses on the effects of the early-life psychological stress on learning and memory pattern of hippocampus in adult mice. We also found the mental stress can result in reproductive dysfunction in adult male rats, including the sharp decrease of sperm quality and quantity. We try to uncover the molecular mechanism of this stress effect via behavioral, physiological, proteomic, genomic and epigenetic approaches.

Mechanisms of Tumorigenesis：

Investigate the mechanisms by which key signaling pathways regulating cell proliferation, apoptosis, and differentiation contribute to tumor invasion and metastasis. Elucidate the drivers and molecular basis of cellular transformation into cancer from a genomic perspective. Screen biomarkers associated with tumor initiation and progression, and develop novel technologies and methods for clinical diagnosis.

Preside General project of National Natural Science Foundation of China, youth Project of National Natural Science Foundation of China, Science and Technology research project of Shaanxi Province, National post-doctoral Funding project, and Xi'an Jiaotong University campus project, etc.

Patents：

1. Yang J, Du YF, Han L, Xu YG, Zhang LY, Chang YX, Xiao X, Gao SF, Xu JL, Liu X. A serum polypeptide biomarker of interstitial cystitis, human serum albumin and its applications. Patent No. ZL 2025114977585.

2. Xu YG，Zou Q，Yang J，Liu W，Li R，Li K，Guo ZH，Zhang XR，Qiang M，Zhang EY. A method for obtaining splicing epigenetic codes suitable for multi-layer lineage trees. Patent No. ZL 202211042467.3.

3. Xu YG，Zhang BJ，Yang J，Zou Q，Liu W，Guo C，Yao YF，Li K，Li YS，Zhang XR. Methods for analysis of variable splicing patterns and dynamic changes of chromatin state in pedigree trees. Patent No. ZL 202211040493.2.

4. Xu YG，Guo MZ，Yang J，Zou Q，Guo C，Li RF，Yao YF，Li YC，Li YS，Shao JM. Method for identifying key regulatory factors that determine the fate of branching point cells in lineage trees. Patent No. ZL 202211042461.6.

5. Hang C, Guo B, Wang WJ, Wang B, Yang J. The Application of Serum Diagnostic Marker ACLY for Ischemic Biliary Lesions After Liver Transplantation. Patent No. ZL 201911129331.4.

6. Huang C，Yang J，Song TS. A kind of gastric carcinoma serum polypeptide molecular and its application. Patent No. ZL 201210087910.9.

7. Yang J，Huang C，Song TS，Ni L. A new method for detecting gastric carcinoma markers and its application，Patent No. ZL  2013101260209.

8. Yang J，Huang C，Song TS, Chen YN. A serum polypeptide marker SERPINA5-A for autism and its application. Patent No. ZL 201610096309.4.

9. Huang C，Yang J，Song TS. A serum peptide marker APOC1-A and its application for children with autism. Patent No. ZL 201610096458.0.

10. Yang J，Huang C，Song TS, Chen YN. A serum polypeptide marker FABP1-A for autism and its application. Patent No. ZL 201610095160.8.

11. Huang C，Yang J，Song TS. A serum polypeptide marker PF4-A for autism and its application. Patent No. ZL 201610097011.5.