Introduction

Juan Yang, Ph.D, Prof. Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center.

Address: Health Science Center, Xi'an Jiaotong University, 76 West Yanta Road, Xi 'an Shaanxi, 710061, P.R. China

E-mail: yangjuan0112@xjtu.edu.cn

WeChat:

2019.01- Present:  Professor, School of Basic Medical Sciences, Xi’an Jiaotong University, China.

2018.06- Present: Doctoral Supervisor, School of Basic Medical Sciences, Xi’an Jiaotong University, China.

2017.09-2018.09: Visiting Scholar, School of Biomedical Informatics, Health Science Center at Houston, The University of Texas, USA.

2013.06- Present: Master's Supervisor, School of Basic Medical Sciences, Xi’an Jiaotong University, China.

2013.01-2018.12: Associate Professor, School of Basic Medical Sciences, Xi’an Jiaotong University, China.

2008.07-2012.12:  Lecturer, School of Basic Medical Sciences, Xi’an Jiaotong University, China.

Biomarkers:

My research focuses on the identification and validation of biomarkers for early diagnosis and treatment of Cancers or other diseases based on proteomic and genomic analyses. Also investigated the candidate molecules function by cell biology and early diagnosis and treatment of Cancers or other diseases based on proteomic and molecular biology techniques.

Psychological Stress & disease:

My research also focuses on the effects of the early-life psychological stress on learning and memory pattern of hippocampus in adult mice. We also found the mental stress can result in reproductive dysfunction in adult male rats, including the sharp decrease of sperm quality and quantity. We try to uncover the molecular mechanism of this stress effect via behavioral, physiological, proteomic, genomic and epigenetic approaches.

Mechanisms of Tumorigenesis：

Investigate the mechanisms by which key signaling pathways regulating cell proliferation, apoptosis, and differentiation contribute to tumor invasion and metastasis. Elucidate the drivers and molecular basis of cellular transformation into cancer from a genomic perspective. Screen biomarkers associated with tumor initiation and progression, and develop novel technologies and methods for clinical diagnosis.

Preside General project of National Natural Science Foundation of China, youth Project of National Natural Science Foundation of China, Science and Technology research project of Shaanxi Province, National post-doctoral Funding project, and Xi'an Jiaotong University campus project, etc.

Representative Publications：

1. Zhang L, Gao S, Xiong X, Liu X, Li R, Wang X, Han L, Xiao X, Wang X, Li W, Chang Y, Du Y, Yang J*. Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress-Related Male Reproductive Dysfunction. Adv Sci (Weinh). 2025 Dec;12(48):e04817.
2. Wang X^#, Gao S^#, Chen L^#, Zhang L, Liu X, Yin C, Xiao X, Xiong X**, Yang J*. Cognitive impairment induced by psychological stress is time-of-day of exposure dependent in female rats. Brain Res. 2025 Sep 15;1863:149837.
3.  Li R^#, Du Y^#, Li K, Xiong X, Zhang L, Guo C, Gao S, Yao Y, Xu Y*, Yang J*. Single-cell transcriptome profiling implicates the psychological stress-induced disruption of spermatogenesis. Mol Ther Nucleic Acids. 2024; 35(1):102158.
4. Huang J, Xiao X, Zhang L, Gao S, Wang X, Yang J*. The effect of serum calcium on the association of depression with infertility among U.S. women. Heliyon. 2023; 9(11):e22220.
5. Xiong X, Zhang S, Zang L, Xin Y, Pang Y, Zhang S, Yang Y, Tu R, Zhang L, Du Y*, Yang J*. Cell apoptosis in the testis of male rats is elevated by intervention with β-endorphin and the mu opioid receptor. Reprod Biol. 2023; 23(3):100789.
6. Gao S, Zhang L, Wang X, Li R, Han L, Xiong X, Jiang Q, Cheng D, Xiao X, Li H*, Yang J*. A terrified-sound stress causes cognitive impairment in female mice by impairing neuronal plasticity. Brain Res. 2023; 1812:148419.
7. Liu H, Zhang J, Liu L, Lian G, Shi R, Xu M, Yang J*, Liu X*. Global Disease Burden and Attributable Risk Factor Analysis of Asthma in 204 Countries and Territories From 1990 to 2019. Allergy Asthma Immunol Res. 2023; 15(4):473-495.
8. Huang J, Hu L, Yang J*. Dietary zinc intake and body mass index as modifiers of the association between household pesticide exposure and infertility among US women: a population-level study. Environ Sci Pollut Res Int. 2023; 30(8): 20327-20336.
9. Fan M, Xiong X, Han L, Zhang L, Gao S, Liu L, Wang X, Huang C, Tong D, Yang J*, Zhao L*, Shao Y*. SERPINA5 promotes tumour cell proliferation by modulating the PI3K/AKT/mTOR signalling pathway in gastric cancer. J Cell Mol Med. 2022; 26(18):4837-4846.
10. Xiong X, Wu Q, Zhang L, Gao S, Li R, Han L, Fan M, Wang M, Liu L, Wang X, Zhang C, Xin Y, Li Z, Huang C, Yang J*. Chronic stress inhibits testosterone synthesis in Leydig cells through mitochondrial damage via Atp5a1. J Cell Mol Med. 2022; 26(2):354-363.
11. Li R, Li L, Xu Y*, Yang J*. Machine learning meets omics: applications and perspectives. Brief Bioinform. 2022; 23(1):bbab460.
12. Fan MY, Liu SY, Zhang LY, Gao SF, Li RF, Xiong XF, Han L, Xiao X, Zhao LY, Tong DD, Yang J*. LGR6 Acts as an Oncogene and Induces Proliferation and Migration of Gastric Cancer Cells. Crit Rev Eukar Gene. 2022; 32(4):11-20.
13. Han L, Yan Y, Fan M, Gao S, Zhang L, Xiong X, Li R, Xiao X, Wang X, Ni L, Tong D, Huang C*, Cao Y*, Yang J*. Pt3R5G inhibits colon cancer cell proliferation through inducing ferroptosis by down-regulating SLC7A11. Life Sci. 2022; 306: 120859.
14. Huang J, Hu L, Yang J*. Dietary Magnesium Intake Ameliorates the Association Between Household Pesticide Exposure and Type 2 Diabetes: Data From NHANES, 2007-2018. Front Nutr. 2022; 9: 903493.
15. Xiong X, Han L, Fan M, Zhang L, Liu L, Guo C, Wu Q, Wang X, Sun R, Ni L, Huang C*, Yang J*. Early maternal deprivation impairs learning and memory and alters hippocampal gene expression in adult male rats. Neurobiol Learn Mem. 2021; 183:107479.
16. Wu S, Zang Q, Xing Z, Li X, Leng J, Liu Y, Wang X*, Yang J*. A Pan-Cancer Analysis of the BIRC Gene Family and Its Association with Prognosis, Tumor Microenvironment, and Therapeutic Targets. Crit Rev Eukaryot Gene Expr. 2021; 31(4): 35-48.
17. Zhang S, Zhao Z, Duan W, Li Z, Nan Z, Du H, Wang M, Yang J*, Huang C*. The Influence of Blood Collection Tubes in Biomarkers' Screening by Mass Spectrometry. Proteomics Clin Appl. 2020; 14(5):e1900113.
18. Xiong X, Zhang L, Fan M, Han L, Wu Q, Liu S, Miao J, Liu L, Wang X, Guo B, Tong D, Ni L, Yang J*, Huang C*. β-Endorphin Induction by Psychological Stress Promotes Leydig Cell Apoptosis through p38 MAPK Pathway in Male Rats. Cells. 2019; 8(10): 1265.
19. Duan B, Hu X, Fan M, Xiong X, Han L, Wang Z, Tong D, Liu L, Wang X, Li W, Yang J*, Huang C*. RNA-Binding Motif Protein 6 is a Candidate Serum Biomarker for Pancreatic Cancer. Proteomics Clin Appl. 2019; 13(5): e1900048.
20. Liu L, Luo M, Xiong X, Zhao L, Wang X, Ni L, Yang J*, Huang C*. Peptidome profiles in melamine diet-induced bladder stones in C57BL/6 mice. Toxicol Appl Pharmacol. 2019; 385:114786.
21. Duan B, Bai J, Qiu J, Wang J, Tong C, Wang X, Miao J, Li Z, Li W, Yang J*, Huang C*. Histone-lysine N-methyltransferase SETD7 is a potential serum biomarker for colorectal cancer patients. 2018; 37:134-143.
22.  Xiong X, Han L, Liu S, Miao J, Luo M, Xue M, Wang X, Ni L, Yang J*, Huang C*. Music intervention improves spatial learning and memory and alters serum proteomics profiling in rats. J Neurosci Res. 2018; 96(10): 1727-1736.
23. Yang J, Chen Y, Xiong X, Zhou X, Han L, Ni L, Wang W, Wang X, Zhao L, Shao D, Huang C*. Peptidome Analysis Reveals Novel Serum Biomarkers for Children with Autism Spectrum Disorder in China. Proteomics Clin Appl. 2018; 12 (5): e1700164.
24. Yang J, Li W, Liu S, Yuan D, Guo Y, Jia C, Song T, Huang C*. Identification of novel serum peptides biomarkers for high-altitude adaptation: a comparative approach. Sci Rep. 2016; 6: 25489.
25. Yang J, Xiong X, Liu S, Zhu J, Luo M, Liu L, Zhao L, Qin Y, Song TS, Huang C*, Identification of novel serum peptides biomarkers for female breast cancer patients in Western China. Proteomics. 2016; 16(6): 925-934.
26.  Yang J, Xiong X, Wang X, Guo B, He K, Huang C*. Identification of peptide regions of SERPINA1 and ENOSF1 and their protein expression as potential serum biomarkers for gastric cancer. Tumour Biol. 2015; 36(7): 5109-5118.
27. Yang J, Zhu J, He K, Zhao L, Song T, Huang C*. Proteomic Profiling of Invasive Ductal Carcinoma (IDC) using Magnetic Beads-based Serum Fractionation and MALDI-TOF MS. J Clin Lab Anal. 2015; 29(4): 321-327.
28. Yang J, Hu L, Wu Q, Liu L, Zhao L, Zhao X, Song T, Huang C*, A terrified-sound stress induced proteomic changes in adult male rat hippocampus. Physiol Behav. 2014; 128: 32-38.
29. Yang J, Yang J, Gao Y, Zhao L, Liu L, Qin Y, Wang X, Song T, Huang C*. Identification of potential serum proteomic biomarkers for clear cell renal cell carcinoma. Plos One. 2014; 9(11): e111364.
30. Yang J, Hu L, Song T, Liu Y, Wu Q, Zhao L, Liu L, Zhao X, Zhang D, Huang C*, Proteomic Changes in female rat hippocampus following exposure to a Terrified Sound Stress, J Mol Neurosci. 2014; 53(2): 158-165.
31. Yang J, Hu LL, Liu LY, Zhao LY, Hou N, Ni L, Li ZF, Wang AY, Song TS, Huang C*. Proteomics Reveals Intersexual Differences in the Rat Brain Hippocampus. Anat Rec (Hoboken). 2013; 296:462–469.
32. Yang J, Song YC, Dang CX, Song TS, Liu ZG,Guo YM, Li ZF, Huang C*. Serum peptidome profiling in patients with gastric cancer. Clin Exp Med. 2012; 12(2):79-87.
33. Yang J, Song YC, Song TS, Guo YM, Li ZF, Dang CX*, Huang C*. Identification of novel low-molecular-weight serum peptidome biomarkers for non-small-cell lung cancer (NSCLC). J Clin Lab Anal. 2012; 26:148-154 .
34. Yang J, Yang SY, Hu XY, Huo SF, Shang WL, Li ZF, Ni L, Wang AY, Guo YM, Song TS*, Huang C*. Serum Peptidome Profiling in Patients with Lung Cancer. The Anatomical Record. 2010; 293:2027-2033.
35. Yang J, Wang XM, Li S, Zhao GF*. What is the phylogenetic placement of Dipteronia dyerana Henry? An example of plant species placement based on nucleotide sequences. Plant Biosystems. 2010; 144: 634-643.
36. Yang J, Li S, Sun GL, Yuan YM, Zhao GF*. Population structure and genetic variation in the genus Dipteronia Oliv. (Aceraceae) endemic to China as revealed by cpSSR analysis. Plant systematic and evolution. 2008. 272:97-106.
37. Yang J, Qian ZQ, Liu ZL, Li S, Sun GL, Zhao GF*. Genetic diversity and geographical differentiation of Dipteronia Oliv. (a genus endemic to China ) revealed by AFLP analysis. Biochemical Systematics and Ecology. 2007. 35:593-599.
38. Li P^#, Yang J^#, Ma QY, Wu Z, Huang C, Li XQ, Wang Z*. Biomarkers screening between preoperative and postoperative patients in pancreatic cancer. Asian Pac J Cancer Prev. 2013;14(7):4161-4165.

Patents：

1. Yang J, Du YF, Han L, Xu YG, Zhang LY, Chang YX, Xiao X, Gao SF, Xu JL, Liu X. A serum polypeptide biomarker of interstitial cystitis, human serum albumin and its applications. Patent No. ZL 2025114977585.
2. Xu YG，Zou Q，Yang J，Liu W，Li R，Li K，Guo ZH，Zhang XR，Qiang M，Zhang EY. A method for obtaining splicing epigenetic codes suitable for multi-layer lineage trees. Patent No. ZL 202211042467.3.
3. Xu YG，Zhang BJ，Yang J，Zou Q，Liu W，Guo C，Yao YF，Li K，Li YS，Zhang XR. Methods for analysis of variable splicing patterns and dynamic changes of chromatin state in pedigree trees. Patent No. ZL 202211040493.2.
4. Xu YG，Guo MZ，Yang J，Zou Q，Guo C，Li RF，Yao YF，Li YC，Li YS，Shao JM. Method for identifying key regulatory factors that determine the fate of branching point cells in lineage trees. Patent No. ZL 202211042461.6.
5. Hang C, Guo B, Wang WJ, Wang B, Yang J. The Application of Serum Diagnostic Marker ACLY for Ischemic Biliary Lesions After Liver Transplantation. Patent No. ZL 201911129331.4.
6. Huang C，Yang J，Song TS. A kind of gastric carcinoma serum polypeptide molecular and its application. Patent No. ZL 201210087910.9.
7. Yang J，Huang C，Song TS，Ni L. A new method for detecting gastric carcinoma markers and its application，Patent No. ZL  2013101260209.
8. Yang J，Huang C，Song TS, Chen YN. A serum polypeptide marker SERPINA5-A for autism and its application. Patent No. ZL 201610096309.4.
9. Huang C，Yang J，Song TS. A serum peptide marker APOC1-A and its application for children with autism. Patent No. ZL 201610096458.0.
10. Yang J，Huang C，Song TS, Chen YN. A serum polypeptide marker FABP1-A for autism and its application. Patent No. ZL 201610095160.8.
11. Huang C，Yang J，Song TS. A serum polypeptide marker PF4-A for autism and its application. Patent No. ZL 201610097011.5.