2026
(33)
(32) Tang, Y.; Wu, X.; Cai, S.; Zou, X.; Duan, Z.; Li, J.; Ma, P.; Gao, B.* Enantioselective O/F Exchange of Sulfonimidoyl Fluorides with Alcohols. JACS. (Submitted)
(31) Kishimoto, S.#; Namba, R.#; Hang, R.; Nshikawa, T.; Oikawa, H.; Kawagishi, H.; Ma, P.*; Houk, K. N.*; Watanabe, K.* Chaxine Biosynthesis and Formation Oxidized Steroidal Dervatives by Air Oxidation of Ergosterol. Experimental and Computational Investigations. JOC (Submitted)
(30) Cai, S.#; Wang, S.#; Xu, S.; Duan, X.; Houk, K. N.*; Ma, P.* Origins of Diastereoselectivity of 1,3-Dipolar Cycloadditions of Cyclic Azomethine Ylides and Nitrones to Cyclopentenes. JOC. (Accepted)
(29) Escudero, J.; Yasukawa, T.; Ma, P.; Bianchi, P.; Wang, Z.; Bellosta, V.; Houk, K. N.*; Cossy, J.* N-Alkylsulfonamide Nucleophilicity: Experimental and Computational Assessment of Nitrogen Nucleophilicity of (S)-2-(Iodomethyl)-1-tosylpyrrolidine. Org. Lett. 2026. https://doi.org/10.1021/acs.orglett.5c05226
Synfacts高亮工作: https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2746-7028
2025
(28) Wu, T.; Xie, X.; Wang, S.; Wang, H.; Shi, G.; Sun, J.; Zhao, Y.; Shimizu, Y.; Kanai, M.; Persson, K. A. Persson; Fan, C.; Ma, P.*; Wei, X.* Ligand Controlled Stereodivergent Chain-Walking Reaction of Skipped Enynes. Cell Rep. Phys. Sci. 2025. https://doi.org/10.1016/j.xcrp.2025.103020
(27) Cai, S.; Ye, H.; Yang, X.; Ma, P.*; Xu, S.*; Zhang, Y.* Aqueous Phase Synthesis of Complex Thiazole-Containing Peptides by Condensation of N-Acyl-α-aminonitriles and Cysteine Derivatives. Org. Lett. 2025, 27, 12379–12384. https://pubs.acs.org/doi/10.1021/acs.orglett.5c04028
(26) Hu, L.#; Li, M. #; Sang, Y.#; Zhao, C.#; Huang, J.; Huang, W.; Xue, Y.; Liu, L.; Gu, Y.; Ma, P.*; Xue, X.*; Pan, L.*; Liu, W.* Pseudokinases Catalyze Peptide Cyclization through Thioether Crosslinking. Nat. Chem. 2025. https://doi.org/10.1038/s41557-025-01954-1
中国国家自然科学基金网报道: https://www.nsfc.gov.cn/p1/3381/2825/96640.html
科学网报道: https://news.sciencenet.cn/htmlpaper/2025/10/2025108213046733140618.shtm
(25) Yue, Z.; Hussain, S.; Feng, Y.; Zhu, C.; C.; Liu, C.; Liu, X.; Hao, Y.; Ma, P.*; Gao, R.* Aggregation-Induced Emission-Active Toroidal Micelles from a Conjugated Polymer: A Selective Phototheranostic Nanoplatform for Targeting Gram-Positive Bacteria. ACS Appl. Mater. Interfaces 2025, 17, 32099–32110. https://doi.org/10.1021/acsami.5c06734
(24) Li, Y.; Ye, H.; Wang, S.; Xu, S.; Lear, M. J.; Houk, K. N.; Ma, P.*; Li, J.* Light-Dependent Amide or Thioamide Formation of Acylsilanes with Amines using Elemental Sulfur. Chem. Eur. J. 2025, 31, e202404555. https://doi.org/10.1002/chem.202404555
(23) DeAngelis, C. J.; Goyal, G.; Liss, M. J.; Budwitz, J. E.; Herlihy, M. S.; Conner, A. V.; Wheeler, S. E.; Ma, P.; Li, M.; Houk, K. N.*; Newton, C. G.* Ketenimines as Aza-Dienophiles. J. Am. Chem. Soc 2025, 147, 6087–6094. https://doi.org/10.1021/jacs.4c17174
(22) Pistofidis, A.; Ma, P., Li, Z.; Houk, K. N.*; Scheming, M.* Structures and mechanism of condensation in nonribosomal peptide synthesis. Nature 2025, 638, 270–278. https://www.nature.com/articles/s41586-024-08417-6
Reported by UCLA: https://www.chemistry.ucla.edu/news/houk-schmeing-novel-mechanism-of- peptide-formation-in-nrpss/
(21) Zhou, S.; Wang, S.; Yu, C.; Ma, P.*; Rao, B.; Zeng, R*. C─H Amination of Polypropylene with Sodium N‐Chloro‐Amides. Angew. Chem. Int. Ed. 2025, e202516324. https://onlinelibrary.wiley.com/doi/10.1002/anie.202516324
(20) Liu, X.; Wang, S.; Zhang, Y.; Yang, F.; Miao, H.; Ma, P., Guo, L.*; Gao, P.* Copper-catalyzed amidoalkylation of amines via C–C bond cleavage from cyclic oxaziridines. Green Chem. 2025, 27(33), 9882-9887. https://doi.org/10.1039/D5GC03001C
2024
(19) Ma, P.*, Svatunek, D.; Zhu, Z.; Boger, D.; Duan, X.; Houk, K. N.* Computational Studies of Reactions of 1,2,4,5−Tetrazines with Enamines in HFIP and MeOH. J. Am. Chem. Soc. 2024, 146, 18706–18713. https://doi.org/10.1021/jacs.4c06067
西安交通大学新闻网: http://news.xjtu.edu.cn/info/1219/211951.htm
(18) Gutkin, S.; Shelef, O.; Babjaková, Z.; Tomanová, L. A.; Babjak, M.; Spitz, U.; Zhou, Q.; Ma, P.; Houk, K. N.; Shabat, D. Boosting Chemiexcitation of Phenoxy-1,2-Dioxetanes through 7-Norbornyl and Homocubanyl Spirofusion. ChemRxiv. 2024; doi:10.26434/chemrxiv-2024-07rl1
(17) David, M.; Leirikh, T.; Shelef, O.; Gutkin, S.; Kopp, T.; Zhou, Q.; Ma, P.; Fridman, M.; Houk, K. N.; Shabat, D. Chemiexcitation Acceleration of 1,2-Dioxetanes via a Spiro-Fused Inductive Electron-Withdrawing Motifs. ChemRxiv. 2024; doi:10.26434/chemrxiv-2024-4nr8m
(16) Yan, B.; Ma, P.; Shu, X.; Yin, W.; Guo, W. Merging of Palladium and Organocatalysis Enabled Asymmetric Decarboxylative (2+1) Cycloadditions toward Cyclopropanes. Org. Lett. 2024, 26, 4274. https://doi.org/10.1021/acs.orglett.4c01088
(15) Jiang, B.; Gao, L.; Wang, H.; Sun, Y.; Zhang, X.; Ke, H.; Liu, S.; Ma, P.; Liao, Q.; Wang, Y.; Wang, H.; Liu, Y.; Du, R.; Rogge, T.; Li, W.; Shang, Y.;
Houk, K. N.; Xiong, X.; Xie, D.; Huang, S.; Lei, X.; Yan, J. Characterization and Heterologous Reconstitution of Taxus Biosynthetic Enzymes Leading to
Baccatin III. Science 2024, 383 (6683), 622–629. https://doi.org/10.1126/science.adj3484.
(14) Tannous, R.; Shelef, O.; Gutkin, S.; David, M.; Leirikh, T.; Ge, L.; Jaber, Q.; Zhou, Q.; Ma, P.; Fridman, M.; Spitz, U.; Houk, K. N.;Shabat, D.
Spirostrain-Accelerated Chemiexcitation of Dioxetanes Yields Unprecedented Detection Sensitivity in Chemiluminescence Bioassays. ACS Cent. Sci. 2024, 10 (1), 28–42. https://doi.org/10.1021/acscentsci.3c01141.
2023
(13) Roy, S.#; Vargas, D. A.#; Ma, P.#; Sengupta, A.; Zhu, L.; Houk, K. N.; Fasan, R. Stereoselective Construction of β-, γ- and δ-Lactam Rings via Enzymatic C–H Amidation. Nat Catal 2023, 7 (1), 65–76. https://doi.org/10.1038/s41929-023-01068-2.（共同一作)
Reported by C&EN: https://cen.acs.org/synthesis/biocatalysis/Engineered-enzyme-constructs-lactams/101/web/2023/12
Reported by RSC's Chemistry World: https://www.chemistryworld.com/news/biocatalysis-breakthrough-enables-synthesis-of-lactam-building-
blocks-for-drugs/4018553.article
Reported by UCLA: https://www.chemistry.ucla.edu/news/chemists-design-enzymes-to-synthesize-lactam-drugs/
Selected by Benjamin List and Marian Guillen as SynFact of the month in the organo- and biocatalysis category: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1773112
(12) Yeh, A. H.-W.; Norn, C.; Kipnis, Y.; Tischer, D.; Pellock, S. J.; Evans, D.; Ma, P.; Lee, G. R.; Zhang, J. Z.; Anishchenko, I.; Coventry, B.; Cao, L.;
Dauparas, J.; Halabiya, S.; DeWitt, M.; Carter, L.; Houk, K. N.; Baker, D. De Novo Design of Luciferases Using Deep Learning. Nature 2023, 614 (7949), 774–780. https://doi.org/10.1038/s41586-023-05696-3.
(11) Liu, S.#; Ma, P.#; Zhang, L.; Shen, S.; Miao, H.-J.; Liu, L.; Houk, K. N.; Duan, X.-H.; Guo, L.-N. A Cheap Metal Catalyzed
Ring Expansion/Cross-Coupling Cascade: A New Route to Functionalized Medium-Sized and Macrolactones. Chem. Sci. 2023, 14 (19), 5220–5225. https://doi.org/10.1039/D2SC06157K. （共同一作）
2022
(10) He, X.#; Ma, P.#; Tang, Y.; Li, J.; Shen, S.; Lear, M. J.; Houk, K. N.; Xu, S. Phosphine-Catalyzed Activation of Cyclopropenones: A Versatile C 3 Synthon for (3+2) Annulations with Unsaturated Electrophiles. Chem. Sci. 2022, 13 (43), 12769–12775. https://doi.org/10.1039/D2SC04092A. （共同一作）
(9) Wang, S.; Ma, P.; Shaik, S.; Chen, H. Valence-Inverted States of Nickel(II) Complexes Perform Facile C–H Bond Activation. J. Am. Chem. Soc. 2022, 144 (32), 14607–14613. https://doi.org/10.1021/jacs.2c03835.
2021
(8) Zuo, L.#; Ma, P.#; Liu, T.; Chen, X.; Lavroff, R. H.; Chen, W.-P.; Houk, K. N.; Guo, W. Ambiphilic Reactivity of Vinyl Pd-Oxyallyl for Expeditious Construction of Highly Functionalized Cyclooctanoids. Org. Lett. 2021, 23 (19), 7330–7335. https://doi.org/10.1021/acs.orglett.1c02401. （共同一作）
(7) Liu, Q.; Long, L.; Ma, P.; Ma, Y.; Leng, X.; Xiao, J.; Chen, H.; Deng, L. Synthesis, Structure, and C–H Bond Activation Reaction of an Iron(IV) Terminal Imido Complex Bearing Trifluoromethyl Groups. Cell Rep. Phys. Sci. 2021, 2 (6), 100454. https://doi.org/10.1016/j.xcrp.2021.100454.
(6) Chen, P.-P.#; Ma, P.#; He, X.; Svatunek, D.; Liu, F.; Houk, K. N. Computational Exploration of Ambiphilic Reactivity of Azides and Sustmann’s
Paradigmatic Parabola. J. Org. Chem. 2021, 86 (8), 5792–5804. https://doi.org/10.1021/acs.joc.1c00239. （共同一作）
Ph.D. Research（2014.09-2020-01）
(5) Ma, P.; Wang, S.; Chen, H. Reactivity of Transition-Metal Complexes in Excited States: C–O Bond Coupling Reductive Elimination of a Ni(II) Complex Is Elicited by the Metal-to-Ligand Charge Transfer State. ACS Catal. 2020, 10 (1), 1–6. https://doi.org/10.1021/acscatal.9b03827.
(4) Ma, P.; Chen, H. Ligand-Dependent Multi-State Reactivity in Cobalt(III)-Catalyzed C–H Activations. ACS Catal. 2019, 9 (3), 1962–1972. https://doi.org/10.1021/acscatal.8b04532.
(3) Han, B.#; Ma, P.#; Cong, X.; Chen, H.; Zeng, X. Chromium- and Cobalt-Catalyzed, Regiocontrolled Hydrogenation of Polycyclic Aromatic Hydrocarbons: A Combined Experimental and Theoretical Study. J. Am. Chem. Soc. 2019, 141 (22), 9018–9026. https://doi.org/10.1021/jacs.9b03328. （共同一作）
(2) Cong, X.#; Fan, F.#; Ma, P.#; Luo, M.; Chen, H.; Zeng, X. Low-Valent, High-Spin Chromium-Catalyzed Cleavage of Aromatic Carbon–Nitrogen
Bonds at Room Temperature: A Combined Experimental and Theoretical Study. J. Am. Chem. Soc. 2017, 139 (42), 15182–15190.
https://doi.org/10.1021/jacs.7b08579. （共同一作）
(1) Zhou, B.; Ma, P.; Chen, H.; Wang, C. Amine-Accelerated Manganese-Catalyzed Aromatic C–H Conjugate Addition to α,β-Unsaturated Carbonyls. Chem. Commun. 2014, 50 (93), 14558–14561. https://doi.org/10.1039/C4CC07598F.